Celebrex

What Is Celebrex?

Celebrex is in a group of drugs called nonsteroidal anti-inflammatory drugs.Celebrexworks by reducing hormones that cause inflammation and pain.

It is used to treat pain or inflammation caused by many conditions such as arthritis, ankylosing spondylitis, and menstrual pain. It is also used in the treatment of hereditary polyps in the colon

Celebrex is a nonsteroidal anti-inflammatory drug (NSAID), specifically a COX-2 inhibitor, which relieves pain and swelling . It is used to treat arthritis, acute pain, and menstrual pain and discomfort. The pain and swelling relief provided by this medication helps you perform more of your normal daily activities. Celecoxib is also used to decrease growths found in the intestines of persons with a family history of this condition.

Celebrex works by blocking the enzyme in our which makes prostaglandins. Decreasing prostaglandins helps to reduce pain and swelling.

How To Use Celebrex?

Nearly a decade after reports first surfaced linking the prescription pain reliever Celebre to an increased risk of heart attack, and two years after the American Heart Association (AHA) warned against the drug for people at risk of heart problems, about 11 million prescriptions for it are still filled each year, often for arthritis, menstrual cramps, and acute pain.

DOSING: The lowest effective dose should be used for each patient.

* For the management of osteoarthritis, the dose usually is 100 mg twice daily or 200 mg as a single dose.
* For rheumatoid arthritis, the dose usually is 100 or 200 mg twice daily.
* For acute pain or menstrual cramps, the dose is 400 mg as a single dose on the first day followed by an additional 200 mg if needed, then 200 mg twice daily as needed.
* For FAP, the recommended dose is 400 mg twice daily.

DRUG INTERACTIONS: Concomitant use of celecoxib with aspirin or other NSAIDs (for example, ibuprofen, naproxen, etc.) may increase the occurrence of stomach and intestinal ulcers. It may be used with low dose aspirin.

Fluconazole (Diflucan) increases the concentration of celecoxib in the body by preventing the elimination of celecoxib in the liver. Therefore, treatment with celecoxib should be initiated at the lowest recommended doses in patients who are taking fluconazole.

Celecoxib increases the concentration of lithium in the blood by 17% and may promote lithium toxicity. Therefore, lithium therapy should be closely monitored during and after therapy with celecoxib.

Why? Well, maybe it's no coincidence that Pfizer, maker of celecoxib, has resumed heavily advertising it directly to consumers, spending $54.8 million on ads in 2007 and $58.5 million in 2008. A new ad—a full two minutes long, and also available online at www.celebrex.com depicts a man walking a dog and riding a bike. It suggests that the drug is no riskier than other related nonsteroidal anti-inflammatory drugs, such as ibuprofen (Advil and generic) and naproxen (Aleve and generic).


Celebrex Side Effects
In light of the recent Vioxx recall, Celebrex side effects are being closely examined, and there are concerns that similar problems may exist with this popular anti-inflammatory drug as well.

Doctors prescribe Celebrex for the treatment of osteoarthritis, rheumatoid arthritis, and other painful conditions. But, the FDA has recently issued a warning regarding potential Celebrex adverse side effects for those patients who use the drug for an extended period of time.

According to a study sponsored the National Cancer Institute, for individuals who took 400 to 800mg daily of Celebrex heart attack risk increased. In addition, preliminary reports from several long-term studies sponsored by the National Institute of Health point to similar risks for users of Celebrex. The FDA also linked Celebrex to bleeding stomach ulcers, liver damage, kidney failure and fluid retention.

However, for now, the FDA has concluded that the benefits of the drug outweigh the potential Celebrex adverse side effects, as long as doctors properly select patients and inform their patients of the drugÕs dangers. The danger of a Celebrex heart attack was not enough for the FDA to pull the plug on this drug for the moment.

How similar are the two pain relievers Vioxx and Celebrex? And, are Celebrex side effects the same as those associated with Vioxx? Celebrex and Vioxx are both types of selective NSAIDs known as COX-2 inhibitors. The FDA encouraged the manufacturers of Vioxx to remove the product from the market in September 2004, because studies associated it with adverse side effects, such as increased heart attack and stroke risk, as well as increased danger of gastrointestinal bleeding. The side effects of Vioxx are identical to the Celebrex side effects; however, the FDA believes the risk of a Celebrex heart attack or GI bleeding related to Celebrex is lower.

Celebrex is also related to the nonselective NSAIDs, such as Ibuprofen, known also by the brand names of Motrin and Advil, to name a few. In fact, the FDA recently advised manufacturers to revise their labeling and provide more specific information about the potential heart attack and gastrointestinal risks of their individual products. The FDA admits that its review board has not conducted long-term controlled clinical trials with most of these NSAIDs. They conclude, however, that the available data suggest that use of these drugs may pose a cardiovascular risk, similar to the Celebrex heart attack risk.

Do Celebrex users have other options to help ease their pain and inflammation? Yes, other options do exist. Fortunately, reputable vitamin and supplement manufacturers offer a host of natural anti-inflammatory supplements such as glucosamine, chondroitin, and an organic sulfur compound known as MSM. Pain sufferers can avoid Celebrex adverse side effects by taking natural supplements. Instead of tricking the body into not receiving pain signals, these supplements go straight to the cause of the disease by strengthening and rebuilding connective tissue.

Despite the FDA's go-ahead to leave Celebrex on the market, whether the Celebrex heart attack risk outweighs its effectiveness in treating pain remains to be fully tested. More studies are underway to determine how detrimental the Celebrex side effects truly are to pain sufferers.

Celebrex Alternatives
Celebrex is a prescription medication licensed to treat several conditions related to pain and inflammation. It is part of a class of drugs called nonsteroidal anti-inflammatory drugs, or NSAIDs for short. Celebrex is a specific type of NSAID known as a COX-2 inhibitor. It is the last COX-2 inhibitor left on the market, as the others have been withdrawn due to safety concerns. With no other COX-2 inhibitors available, alternatives to Celebrex are limited to other types of medications or treatments.

Some of the possible substitutes include:

o Other medications
o Non-medication pain relief options, such as:
o Exercise and weight control
o Surgery
o Alternative therapies.

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Plavix

What is Plavix?

Plavix keeps the platelets in your blood from coagulating (clotting) to prevent unwanted blood clots that can occur with certain heart or blood vessel conditions.

Plavix is used to prevent blood clots after a recent heart attack or stroke, and in people with certain disorders of the heart or blood vessels.


About PLAVIX

PLAVIX (clopidogrel bisulfate) helps keep platelets in the blood from sticking together and forming clots, which are the direct cause of most heart attacks and strokes. It is recommended for people who have experienced a recent clot-related event—such as a heart attack or stroke—or who have been diagnosed with Peripheral Artery Disease, or P.A.D (also known as poor circulation in the legs).



PLAVIX (clopidogrel bisulfate), taken with aspirin, is also recommended for people who have Acute Coronary Syndrome (ACS), a diagnosis that includes heart-related chest pain (unstable angina) and 2 types of heart attack. Each of these conditions increases the risk for a future heart attack or stroke. Always talk to your doctor before taking aspirin or other medicines with PLAVIX, especially if you've had a stroke.
Plavix

How PLAVIX Works

PLAVIX helps protect you from a future heart attack or stroke.

In most cases, a heart attack or stroke is caused by a blood clot that reduces or blocks the flow of blood through an artery. PLAVIX helps keep platelets in the blood from sticking together and forming blood clots. By keeping your blood flowing, PLAVIX helps protect you from blood clots and a future heart attack or stroke.

PLAVIX is recommended for people who have suffered from a recent heart attack or recent stroke, or who have been diagnosed with Peripheral Artery Disease, or P.A.D., also known as poor circulation in the legs. Each of these conditions increases the risk for a future heart attack or stroke.

PLAVIX, taken with aspirin, is also recommended for people who have Acute Coronary Syndrome (ACS), a diagnosis that includes heart-related chest pain (unstable angina) and the 2 types of heart attack—acute ST-segment elevation myocardial infarction ("STEMI") and non-ST-segment elevation myocardial infarction ("NSTEMI"). If you have been hospitalized with heart-related chest pain (unstable angina) or had a STEMI heart attack, you, too, are at a higher risk for dangerous blood clots and a future heart attack or stroke.

Always talk to your doctor before taking aspirin or other medicines with PLAVIX, especially if you’ve had a stroke.

PLAVIX has been the focus of extensive research, studies, and scientific findings. The effectiveness of PLAVIX has been proven and the safety profile supported by 4 large clinical studies involving 81,000 patients.


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Orthovisc

What Is Orthovisc?

Orthovisc is a solution of high molecular weight hyaluronan. Orthovisc is similar to healthy human synovial fluid, a substance that lubricates the joints.

Orthovisc is one of the hyaluronates used in viscosupplementation. Orthovisc is injected directly into the knee joint to restore the cushioning and lubricating properties of normal joint fluid.

Orthovisc is indicated for the treatment of knee pain in osteoarthritis of the knee for those who have failed to respond to more conservative therapy. Use for other joints is being investigated.


Orthovisc (High Molecular Weight Hyaluronan) is an FDA-approved non-drug therapy that can give you relief and get you back to your life. Orthovisc is the only non-avian sourced viscosupplementation with lasting efficacy for up to 6 months. Orthovisc is derived from bacterial cells.

When exercise and simple pain medications no longer work for your knee pain due to osteoarthritis (OA) of the knee,Orthovisc may be the answer.Orthoviscis the only injection made from ultra-pure natural hyaluronan—which is naturally found in healthy joint fluid.

Orthovisc injection given as 1 injection for 3 consecutive weeks helps restore healthy joint fluid to cushion, protect and lubricate your knee joint. ORTHOVISC® can relieve your knee pain for up to 6 months. Although individual results may vary, some people feel pain relief after the first injection.

Talk to your doctor to see if Orthovisc might be a good choice to relieve your knee pain.

How to use Orthovisc:

Read the Patient Information Leaflet provided by your health care professional before you start using hyaluronate and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Your doctor will give this medication by injection into the affected joint, usually once a week. Skin disinfectants that contain ammonium salts (such as benzalkonium chloride) should not be used to prepare the injection site. Your doctor may need to remove extra fluid from the joint before injecting the medicine. Dosage is based on your medical condition and response to treatment.

Hyaluronate should not be injected into a vein or artery because increased side effects may occur.

After receiving an injection of hyaluronate, you should avoid any activities that put stress on your knee (such as jogging, tennis, heavy lifting, standing on your feet for more than an hour) for 48 hours.

Also, after the injection, you may experience increased pain and swelling in the knee at first. If the pain or swelling continues or worsens, talk to your doctor promptly.

It is important to have this medication injected on schedule. It may take up to 3 injections before the full benefits of this medication occur.

Tell your doctor if your condition persists or worsens.

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Phentermine

What Is Phentermine?
Generic Name: phentermine Brand Names: Fastin, Adipex-P, Ionamin. What is phentermine? Phentermine is a sympathomimetic amine, similar to an amphetamine. Phentermine stimulates the central nervous system, which increases your blood pressure and heart rate and decreases your appetite. Phentermine is used as a temporary supplement to diet and exercise plans in the treatment of obesity.

Phentermine is used as an appetite suppressant. Preparations: tablets: 30mg, 37.5mg. It is used in conjunction with an overall diet plan to reduce weight. To accept Phentermine it is necessary in one-half hour before breakfast and it is necessary on an empty stomach. Do not accept Phentermine before sleep, it may cause insomnia in some people.

Unfortunately there are also side effects of use Phentermine. In the first few days of reception you may have insomnia, a dry mouth, frustration of a stomach or constipation. If these effects are present long time, inform your doctor.

Precautions, before application Phentermine, necessarily consult to your doctor. Also inform your doctor about all the medicines you use. If you have high blood pressure, arteriosclerosis, glaucoma, an overactive thyroid gland, diabetic or you are pregnant, your doctor may forbid use Phentermine. Also Phentermine is not recommended for use by children.

Remember that Phentermine it is impossible to use with others weight loss diet pills. If you miss a dose, do not double the following dose. Store Phentermine at room temperature far from a sunlight and humidity.

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Xenical

What Is Xenical?

Xenical is a prescription weight control medication useful for the long term treatment of significant obesity. Each xenical capsule contains 120 mg of the active substance orlistat, which acts as a lipase inhibitor.

Basic action Xenical this absorption of fat in your body. Dietary fats are inhibited from being absorbed and this allows about 30% of the fat eaten in the meal to pass thorough the gut undigested. This helps you to reduce and maintain your weight. Xenical it is possible to accept three times per day, this medicine should be swallowed with water. Xenical is not intended to be used by children or pregnant and nursing mothers.

Unfortunately there are also side effects of use Xenical. In the beginning of treatment loose stools and increase gas or flatulence are possible. Usually, these attributes disappear, if you continue treatment.

Precautions, Xenical reduces the absorption of supplements of some fat soluble nutrients, particularly beta-carotene and vitamin E. You should therefore follow your doctor's advice in taking a well balanced diet rich in fruit and vegetables.

Remember if you miss a dose, do not double the following dose. Store Xenical at room temperature far from a sunlight and humidity.

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Euflexxa Injections

Euflexxa injections (highly purified hyaluronan) information, dosage, indications, side effects, drug interactions, and warnings. Euflexxa is one of the hyaluronates used in viscosupplementation. Euflexxa is a treatment for osteoarthritis which is injected directly into the knee joint. Euflexxa is the first hyaluronic acid that is not derived from an avian source.

What is Euflexxa?

Euflexxa is an ultra-high purity hyaluronan, also called hyaluronic acid (HA) or sodium hyaluronate. Euflexxa is similar to healthy human synovial fluid, a substance that lubricates the joints.

Euflexxa is one of the hyaluronates used in viscosupplementation. Euflexxa is injected directly into the knee joint to restore the cushioning and lubricating properties of normal joint fluid.

Euflexxa is indicated for the treatment of knee pain in osteoarthritis of the knee in patients who have failed to respond to more conservative non-pharmacologic therapy and to simple Use for other joints is being investigated.

How to use Euflexxa

Read the Patient Information Leaflet provided by your health care professional before you start using hyaluronate and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Your doctor will give this medication by injection into the affected joint, usually once a week. Skin disinfectants that contain ammonium salts (such as benzalkonium chloride) should not be used to prepare the injection site. Your doctor may need to remove extra fluid from the joint before injecting the medicine. Dosage is based on your medical condition and response to treatment.

Hyaluronate should not be injected into a vein or artery because increased side effects may occur.

After receiving an injection of hyaluronate, you should avoid any activities that put stress on your knee (such as jogging, tennis, heavy lifting, standing on your feet for more than an hour) for 48 hours.

Also, after the injection, you may experience increased pain and swelling in the knee at first. If the pain or swelling continues or worsens, talk to your doctor promptly.

It is important to have this medication injected on schedule. It may take up to 3 injections before the full benefits of this medication occur.

Tell your doctor if your condition persists or worsens.

Hyalgan

What Is Hyalgan?
Hyalgan is a solution of sodium hyaluronate. Hyaluronate is a natural chemical found in the body.

Hyalgan is one of the hyaluronates used in viscosupplementation.

Hyalgan is injected directly into the knee joint to restore the cushioning and lubricating properties of normal joint fluid.

Hyalgan is used to relieve knee pain due to osteoarthritis, for those who failed to respond to simple painkillers, exercise or physical therapy.

Fast Facts About Hyalgan Injections:

* Viscosupplementation has been studied for osteoarthritis treatment since the 1970s.
* Hyalgan was FDA approved on 05/28/97.

* Hyalgan injections are typically given once a week, one week apart, for a total of five injections. Some may benefit with only three.

* Hyalgan was the first FDA approved hyaluronan therapy.

* Hyalgan is considered a treatment or therapy, not a drug.

Hyalgan Injections

Hyalgan injections (sodium hyaluronate) information, dosage, indications, side effects, drug interactions, and warnings. Hyalgan is one of the hyaluronates used in viscosupplementation. Hyalgan is a treatment for osteoarthritis which is injected directly into the knee joint.

How to use Hyalgan :

Read the Patient Information Leaflet provided by your health care professional before you start using hyaluronate and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Your doctor will give this medication by injection into the affected joint, usually once a week. Skin disinfectants that contain ammonium salts (such as benzalkonium chloride) should not be used to prepare the injection site. Your doctor may need to remove extra fluid from the joint before injecting the medicine. Dosage is based on your medical condition and response to treatment.

Hyaluronate should not be injected into a vein or artery because increased side effects may occur.

After receiving an injection of hyaluronate, you should avoid any activities that put stress on your knee (such as jogging, tennis, heavy lifting, standing on your feet for more than an hour) for 48 hours.

Also, after the injection, you may experience increased pain and swelling in the knee at first. If the pain or swelling continues or worsens, talk to your doctor promptly.

It is important to have this medication injected on schedule. It may take up to 3 injections before the full benefits of this medication occur.

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