Orthovisc

What Is Orthovisc?

Orthovisc is a solution of high molecular weight hyaluronan. Orthovisc is similar to healthy human synovial fluid, a substance that lubricates the joints.

Orthovisc is one of the hyaluronates used in viscosupplementation. Orthovisc is injected directly into the knee joint to restore the cushioning and lubricating properties of normal joint fluid.

Orthovisc is indicated for the treatment of knee pain in osteoarthritis of the knee for those who have failed to respond to more conservative therapy. Use for other joints is being investigated.


Orthovisc (High Molecular Weight Hyaluronan) is an FDA-approved non-drug therapy that can give you relief and get you back to your life. Orthovisc is the only non-avian sourced viscosupplementation with lasting efficacy for up to 6 months. Orthovisc is derived from bacterial cells.

When exercise and simple pain medications no longer work for your knee pain due to osteoarthritis (OA) of the knee,Orthovisc may be the answer.Orthoviscis the only injection made from ultra-pure natural hyaluronan—which is naturally found in healthy joint fluid.

Orthovisc injection given as 1 injection for 3 consecutive weeks helps restore healthy joint fluid to cushion, protect and lubricate your knee joint. ORTHOVISC® can relieve your knee pain for up to 6 months. Although individual results may vary, some people feel pain relief after the first injection.

Talk to your doctor to see if Orthovisc might be a good choice to relieve your knee pain.

How to use Orthovisc:

Read the Patient Information Leaflet provided by your health care professional before you start using hyaluronate and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Your doctor will give this medication by injection into the affected joint, usually once a week. Skin disinfectants that contain ammonium salts (such as benzalkonium chloride) should not be used to prepare the injection site. Your doctor may need to remove extra fluid from the joint before injecting the medicine. Dosage is based on your medical condition and response to treatment.

Hyaluronate should not be injected into a vein or artery because increased side effects may occur.

After receiving an injection of hyaluronate, you should avoid any activities that put stress on your knee (such as jogging, tennis, heavy lifting, standing on your feet for more than an hour) for 48 hours.

Also, after the injection, you may experience increased pain and swelling in the knee at first. If the pain or swelling continues or worsens, talk to your doctor promptly.

It is important to have this medication injected on schedule. It may take up to 3 injections before the full benefits of this medication occur.

Tell your doctor if your condition persists or worsens.

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